Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Transporter 1, ATP Binding Cassette Subfamily B Member (TAP1)
- Target
- TAP1
- Molecular classification
- ATP-binding cassette (ABC) transporter, Transporter, MDR/TAP subfamily
01
Overview
TAP1 is an ATP-binding cassette (ABC) transporter protein that forms a heterodimer with TAP2 to create the TAP complex. This complex is located in the endoplasmic reticulum membrane and transports peptides derived from cytosolic proteins into the ER. These peptides are then loaded onto MHC class I molecules and presented on the cell surface, initiating an immune response. Mutations in TAP1 can lead to Bare Lymphocyte Syndrome Type I and may be associated with other autoimmune diseases.
- Other names
- ABC transporter MHC 1ABC17ABCB2
02
Mechanism of action
N/A
03
Biological functions
Peptide transportAntigen processingImmune responseAdaptive immunity via CD8+ T-cell activation
04
Disease associations
Bare lymphocyte syndrome type IAnkylosing spondylitisInsulin-dependent diabetes mellitusCeliac diseaseImmunodeficiency
Beyond the preview
Go deeper on Transporter 1, ATP Binding Cassette Subfamily B Member (TAP1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Transporter 1, ATP Binding Cassette Subfamily B Member (TAP1).