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Target intelligence / Profile preview
TRDN antisense RNA 1 (TRDN-AS1)
- Target
- TRDN-AS1
- Molecular classification
- Long non-coding RNA, Antisense RNA, Regulator of gene splicing
01
Overview
TRDN antisense RNA 1 (TRDN-AS1) is a cardiomyocyte-specific lncRNA arising from the antisense strand between exons 9 and 11 of the triadin gene (TRDN). Highly expressed in normal human heart tissue, its primary role is to regulate the alternative splicing and expression levels of the cardiac isoform of triadin, which is vital for calcium homeostasis and electrical activity in the heart. TRDN-AS1 achieves this by interacting with serine/arginine (SR) splicing factors. Its downregulation is strongly correlated with decreased triadin expression in heart failure and cardiac arrhythmias, suggesting involvement in disease pathogenesis. TRDN-AS1 is considered an emerging therapeutic and biomarker target for cardiovascular conditions.
- Other names
- HRAT13heart tissue-associated transcript 13TRDN-AS1
02
Mechanism of action
Not established; future therapies might involve modulation of TRDN-AS1 expression or lncRNA-directed mechanisms such as RNA interference or splicing modulation.
03
Biological functions
Regulation of alternative splicingCardiac calcium homeostasisRegulation of cardiomyocyte-specific gene expression
04
Disease associations
Cardiovascular diseaseCardiac arrhythmiaHeart failureDilated cardiomyopathy
05
Safety considerations
Arrhythmia risk from modulationcardiac contractility riskoff-target RNA therapeutic risks
06
Biomarkers
TRDN-AS1 expression (heart failure, arrhythmias)Gene-expression signature in cardiac disease
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