Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Trefoil factor 1 (TFF1)
- Target
- TFF1
- Molecular classification
- Secreted protein, Trefoil factor
01
Overview
Trefoil factor 1 (TFF1) is a small secreted protein crucial for gastrointestinal mucosal protection and repair. It stabilizes the mucus layer, modulates mucus viscosity, and exhibits both antiproliferative and antiapoptotic effects. While acting as a tumor suppressor in the stomach, it can paradoxically promote tumorigenesis in other contexts. It was originally identified as an estrogen-inducible protein (pS2) in breast cancer cells.
- Other names
- pS2BCEIBreast cancer estrogen-inducible proteinhP1.A
02
Mechanism of action
Unknown, but involves modulation of cell cycle inhibitors (INK4/CIP families) and caspase-9 activity
03
Biological functions
Mucosal protectionMucus modulationAntiproliferativeAntiapoptoticCell differentiation
04
Disease associations
CancerGastric carcinomaBreast cancer
05
Safety considerations
Context-dependent pro-tumoral effects in certain cancers (e.g., prostate, pancreatic)
06
Biomarkers
Breast cancer prognosis
Beyond the preview
Go deeper on Trefoil factor 1 (TFF1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Trefoil factor 1 (TFF1).