Target intelligence / Profile preview

Treponema pallidum

Molecular classification: Bacterium, Spirochete

Overview

Treponema pallidum is a microaerophilic, gram-negative spirochete bacterium and the causative agent of syphilis, bejel, and yaws. It is transmitted primarily through sexual contact. The bacterium has a distinctive helical shape and relies on glycolysis for ATP production, making it an obligate parasite. Its outer membrane structure helps it evade host immune responses. Treatment is highly effective with penicillin G.

Mechanism of action

Inhibition of bacterial cell wall synthesis

Biological functions

InfectionMotilityAdhesionMetabolism (Glycolysis)

Disease associations

SyphilisBejel (Endemic Syphilis)Yaws

Safety considerations

Antibiotic resistance (though currently rare)Jarisch-Herxheimer reaction

Interacting drugs

Penicillin G

Beyond the preview

Go deeper on Treponema pallidum.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Treponema pallidum.

Explore the full profile