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Target intelligence / Profile preview
Trichophyton rubrum
- Molecular classification
- Fungus, Dermatophyte
01
Overview
Trichophyton rubrum is a filamentous, keratinophilic fungus and the most prevalent dermatophyte infecting humans. It is responsible for the majority of superficial fungal infections worldwide, particularly those affecting skin, nails (onychomycosis), and feet (tinea pedis/athlete’s foot). T. rubrum invades keratinized tissues by digesting keratin using secreted enzymes like proteases. Infections range from mild scaling to chronic lesions.
02
Mechanism of action
Inhibition of fungal cell wall synthesis or other fungal-specific targets.
03
Biological functions
Keratin degradationInfectionProtease secretion
04
Disease associations
Tinea pedis (Athlete's foot)Onychomycosis (Nail infection)Tinea corporis (Body ringworm)
05
Safety considerations
Drug resistanceChronic infectionsHost immune response
06
Interacting drugs
Antifungals (e.g., azoles, allylamines)
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