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Tricuspid valve annulus
- Molecular classification
- Other (anatomical structure; not a molecule, enzyme, transporter, or receptor)
01
Overview
The tricuspid valve annulus is a fibrous, saddle-shaped, non-planar ring that forms the structural base of the tricuspid valve, separating the right atrium and right ventricle. It anchors the valve leaflets and undergoes dynamic changes in size and shape during the cardiac cycle. Annular dilation is a key factor in tricuspid regurgitation, particularly in conditions such as atrial fibrillation and right atrial enlargement. The anatomical relationship of the annulus to adjacent critical structures, such as the right coronary artery and the conduction system, has important implications for surgical and interventional procedures.
- Other names
- Tricuspid annulusTVA
02
Biological functions
Maintains the structure and integrity of the tricuspid valveFacilitates proper valve function by providing support for leaflet coaptationModulates the geometry and motion of the tricuspid valve during the cardiac cycle
03
Disease associations
Cardiovascular diseaseTricuspid regurgitationRight heart failureAtrial fibrillation/atrial flutter (context: involvement in cavotricuspid isthmus ablation)Congenital heart disease (e.g., Ebstein's anomaly)
04
Safety considerations
Proximity to the right coronary artery (risk of iatrogenic injury during valve or ablation procedures)Proximity to atrioventricular node/Koch’s triangle (risk of conduction system injury during surgery/ablation)Procedural challenges in tricuspid annulus due to lack of fibrous tissue and dynamic nature
05
Interacting drugs
None (the annulus is not directly targeted by drugs)
06
Biomarkers
Annular dilation by echocardiography is a biomarker for tricuspid regurgitation severity and risk stratification
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