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Tricuspid valve leaflet coaptation
01
Overview
"Tricuspid valve leaflet coaptation" refers to the physical apposition or closure of the leaflets of the tricuspid heart valve, preventing backward flow (regurgitation) through the valve. The extent of leaflet coaptation (and any 'coaptation gap') is an anatomical and diagnostic feature important for characterizing the severity of tricuspid regurgitation and for patient selection and procedural guidance in interventions such as tricuspid edge-to-edge repair (TEER)[1][2][3]. It is not a molecule, protein, or receptor, and thus is not a conventional therapeutic molecular target.
- Other names
- Tricuspid valve leaflet coaptation gapTricuspid leaflet coaptationLeaflet coaptation (tricuspid valve)
02
Disease associations
Cardiovascular disease
03
Safety considerations
Incomplete leaflet coaptation is linked to tricuspid regurgitation and failure of valve repair interventions[1][2][3]
04
Biomarkers
Measurement of coaptation gap may be used as a biomarker for tricuspid regurgitation severity[1][2][3]
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