Trifluridine incorporation into DNA

Trifluridine incorporation into DNA" is not itself a molecular target but rather describes the mechanism by which the antitumor agent trifluridine exerts its effect. Trifluridine is a fluorinated thymidine analogue that becomes incorporated into the DNA of rapidly dividing cells such as tumor cells. This incorporation disrupts normal DNA function by causing strand breaks and defective replication, ultimately inhibiting cell proliferation and inducing apoptosis. The process underlies both the therapeutic efficacy against cancers like metastatic colorectal cancer and certain toxicities such as bone marrow suppression seen with drugs like Lonsurf (trifluridine/tipiracil). Therefore, "trifluridine incorporation into DNA" should be considered an action or mechanism rather than a canonical drug target or receptor.

Incorporation of trifluridine into DNA causes DNA dysfunction, strand breaks, and defective replication leading to inhibition of tumor cell proliferation and induction of cell death