Trifunctional purine biosynthetic protein adenosine–3 (GART)

GART is a trifunctional enzyme essential for the de novo biosynthesis of purines, catalyzing three sequential reactions in the pathway that leads to inosine monophosphate (IMP). It functions as Phosphoribosylamine–glycine ligase (GARS), Phosphoribosylglycinamide formyltransferase (GAR transformylase), and AIR synthetase (AIRS). Inhibition of GART is explored as a target for anticancer therapies due to its role in cell proliferation.

Other names

Adenosine-3Phosphoribosylamine–glycine ligaseGlycinamide ribonucleotide synthetase (GARS)Phosphoribosylglycinamide formyltransferaseGAR transformylaseAIR synthetaseFGAM cyclaseAminoimidazole ribonucleotide synthetase (AIRS)

Inhibition of GART enzymatic activities, disruption of purine nucleotide biosynthesis