Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
- Target
- TREM2
- Molecular classification
- Receptor, Immunoglobulin superfamily, Type I transmembrane protein
01
Overview
TREM2 is a membrane glycoprotein and member of the immunoglobulin superfamily, primarily expressed on myeloid lineage cells. It forms a receptor complex with TYROBP/DAP12 or DAP10 adaptor proteins to mediate intracellular signaling. It regulates microglial survival and activation, phagocytosis, maintenance of brain homeostasis, and modulation of inflammatory responses. Variants are associated with Alzheimer's disease, Nasu-Hakola disease, and cancer, making it a therapeutic target.
02
Biological functions
Immune responsePhagocytosisRegulation of inflammationBrain homeostasisBone remodelingCell survivalSynaptic pruning
03
Disease associations
Alzheimer’s diseaseNasu-Hakola disease / PLOSLCancerNeurodegenerative diseaseInflammation
04
Safety considerations
Balancing beneficial versus detrimental immune responsesMultiple isoforms
05
Biomarkers
sTREM2 (soluble TREM2)
Beyond the preview
Go deeper on Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).