Triglyceride metabolic pathway

The triglyceride metabolic pathway encompasses the biochemical events concerned with the synthesis, storage, breakdown, and transport of triglycerides—molecules composed of glycerol and three fatty acids that are the primary form of stored energy in animals. Synthesis (lipogenesis) occurs mainly in the liver and adipose tissue, with enzymes such as GPAT, AGPAT, and DGAT playing key roles. Triglycerides are stored in adipocytes and can be released as free fatty acids during lipolysis, which supports energy needs during fasting or increased physical activity. Transport through the blood occurs via chylomicrons and VLDL, with processing by lipases in tissues. Dysregulation of this pathway is central to the pathogenesis of metabolic syndrome, diabetes, cardiovascular disease, and other lipid disorders.

Other names

Triglyceride metabolismTriacylglycerol metabolismTG metabolismLipid metabolism pathway

Activation or inhibition of enzymes in triglyceride synthesis/breakdown (e.g., inhibition of lipolysis, activation of lipoprotein lipase) Modulation of lipoprotein production and clearance Inhibition of intestinal absorption or hepatic secretion of triglycerides (e.g., MTTP inhibition)