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Triglyceride Synthesis Pathway (TAG Synthesis)
- Target
- TAG Synthesis
- Molecular classification
- Metabolic Pathway
01
Overview
The triglyceride (also called triacylglycerol, TAG) synthesis pathway is a central metabolic process responsible for the formation of triglycerides from fatty acids and glycerol. Triglycerides are the primary storage form of energy in animals and plants, stored mainly in adipose tissue and seeds. The pathway is highly conserved across species, with key steps occurring predominantly in liver, adipose tissue, intestines, and certain plant tissues. It consists of Fatty acyl-CoA Biosynthesis, Conversion to Phosphatidic Acid, Formation of Diacylglycerol (DAG), and Synthesis of Triacylglycerol.
- Other names
- Triacylglycerol BiosynthesisTriacylglycerol MetabolismTAG Metabolism
02
Mechanism of action
N/A
03
Biological functions
Energy storageLipid metabolismFatty acid metabolismGlycerolipid metabolism
04
Disease associations
ObesityNon-alcoholic steatohepatitis (NASH)Fatty liver diseaseInsulin resistanceType II diabetesMetabolic syndrome
05
Safety considerations
Hypertriglyceridemia (with some ACC inhibitors)Altered lipid fluxes (with some ACC inhibitors)
06
Interacting drugs
ND-630
1 more in the full profile.
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