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Target intelligence / Profile preview
Triiodothyronine Receptor (TR)
- Target
- TR
- Molecular classification
- Nuclear Receptor, Transcription Factor
01
Overview
The triiodothyronine receptor, also known as the thyroid hormone receptor (TR), is a member of the nuclear receptor superfamily. It is activated by binding to thyroid hormones—primarily triiodothyronine (T3) and thyroxine (T4)—and functions as a ligand-dependent transcription factor. TRs regulate metabolism, heart rate, and growth & development, playing essential roles during embryonic development and tissue differentiation.
- Other names
- Thyroid Hormone ReceptorTHR
02
Mechanism of action
Ligand-dependent transcription factor; binds to DNA at thyroid hormone response elements (TREs) and regulates gene expression by recruiting coactivators or corepressors.
03
Biological functions
Regulation of gene expressionRegulation of metabolismRegulation of heart rateRegulation of growth and developmentTissue differentiation
04
Disease associations
Resistance to Thyroid Hormone syndromeThyroid hormone hypersensitivityMetabolic disorders
05
Safety considerations
Resistance to thyroid hormoneThyroid hormone hypersensitivity
06
Interacting drugs
Triiodothyronine (T3)
1 more in the full profile.
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