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Target intelligence / Profile preview
TRIM31 antisense RNA 1 (TRIM31-AS1)
- Target
- TRIM31-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Natural antisense transcript (NAT), Non-protein coding RNA
01
Overview
TRIM31 antisense RNA 1 (TRIM31-AS1) is a long non-coding RNA gene transcribed antisense to the TRIM31 gene locus. It functions as a natural antisense transcript potentially modulating the expression of the TRIM31 protein, a known E3 ubiquitin ligase involved in tumor progression, immune response, and inflammation. Antisense RNAs like TRIM31-AS1 are implicated in transcriptional interference—affecting sense gene transcription via multiple molecular models such as promoter competition, RNAP occlusion, and transcriptional collision. Although the emerging roles of antisense RNAs in gene regulation and chromatin structure are of research interest, there are no clinical drugs, biomarkers, or safety issues directly associated with TRIM31-AS1. Its role in disease is largely indirect, mediated via its regulatory effects on TRIM31.
- Other names
- TRIM31-AS1TRIM31 antisense RNA 1 (non-protein coding)XXbac-BPG250I8.13
02
Mechanism of action
Transcriptional regulation via antisense RNA; potential modulator of TRIM31 gene transcription, RNA stability, and epigenetic imprinting
03
Biological functions
Regulation of gene expression (principally the sense TRIM31 gene)Transcriptional interferenceChromatin remodeling (potentially based on antisense RNA mechanisms)Epigenetic regulation
04
Disease associations
Cancer (potential indirect involvement via regulation of TRIM31, which is implicated in tumor progression and prognosis)Other (based on antisense RNA general functions; no specific disease role for TRIM31-AS1 reported in primary literature)
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