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Target intelligence / Profile preview
Trimethylamine (TMA)
- Target
- TMA
- Molecular classification
- Other (specifically: small molecule, volatile tertiary amine, xenobiotic metabolite)
01
Overview
Trimethylamine is a small, volatile, tertiary amine (chemical formula C₃H₉N) with a strong fishy odor, widely present as a natural byproduct of microbial and animal metabolism, and as a result of the breakdown of compounds like choline and carnitine. It is not a therapeutic "target" in the conventional drug discovery sense (e.g., a protein or nucleic acid). Biologically, trimethylamine has significance as a metabolite implicated in the genetic disorder trimethylaminuria and as a microbial product associated with metabolism of dietary nutrients in the gut, especially as a precursor to trimethylamine N-oxide (TMAO). It has various industrial uses and is classified as hazardous due to its toxicity and flammability.
- Other names
- N,N-dimethylmethanamineMethanamine, N,N-dimethyl-N,N,N-trimethylamineTrimethyl amineTMATRIMETHYLAMMONIUM
02
Biological functions
Other (volatilized metabolite in microbial and animal metabolism, phase I liver substrate)
03
Disease associations
Other (implicated in trimethylaminuria ("fish odor syndrome"), acts as a precursor for trimethylamine N-oxide which is researched for roles in cardiovascular disease)
04
Safety considerations
Flammable, toxic by inhalation; can cause mucous membrane irritationStrong, fishy odor detected at very low concentrations; warning propertyMay cause necrosis of mucous membranes at high concentrations
05
Biomarkers
Urine and plasma trimethylamine levels are biomarkers for trimethylaminuriaPrecursor for trimethylamine N-oxide (TMAO), a biomarker studied in cardiovascular risk
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