Trinucleotide repeat-containing gene 6A protein (TNRC6A)

Trinucleotide repeat-containing gene 6A protein (TNRC6A) is a conserved scaffolding protein that plays an essential role in post-transcriptional gene silencing, particularly in microRNA (miRNA)-mediated regulation and RNA interference (RNAi)[1][2][3][6]. TNRC6A is a central component of the RNA-induced silencing complex (RISC), where it interacts with Argonaute proteins via its N-terminal glycine-tryptophan (GW) repeat motifs and connects the RISC to downstream effector complexes[1][3][4]. Through its silencing domain, TNRC6A recruits complexes such as CCR4–NOT and poly(A)-binding protein to promote translational repression and trigger mRNA deadenylation and degradation[1][2][3][6]. TNRC6A shuttles between the nucleus and cytoplasm, participating not only in the formation and function of cytoplasmic GW/P bodies, which house repressed mRNAs, but also in nuclear gene expression processes[1][3]. Disruption or loss of TNRC6A is associated with impaired miRNA regulation and has been linked to tumorigenesis and altered neuronal development[1][2][6]. There are no reported direct drug interactions or specific therapeutic mechanisms targeting TNRC6A at this time.

Other names

Trinucleotide repeat-containing adaptor 6ACAGH26KIAA1460Protein GW1GW182CAG repeat protein 26EMSY interactor proteinGW182 autoantigenGlycine-tryptophan protein of 182 kDaFAME6GW1TNRC6CTD-2540M10.1EDIE