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Trinucleotide repeat-containing gene 6B protein (TNRC6B)
- Target
- TNRC6B
- Molecular classification
- Other (RNA-binding/scaffolding protein, not a classical receptor, enzyme, transporter, or transcription factor)
01
Overview
Trinucleotide repeat-containing gene 6B protein (TNRC6B) is a ubiquitously expressed RNA-binding protein encoded by the TNRC6B gene on human chromosome 22[1][2]. It functions as a scaffolding adaptor essential for microRNA (miRNA) and short interfering RNA (siRNA) mediated gene silencing through post-transcriptional regulation of mRNAs. TNRC6B interacts with Argonaute proteins and is required for miRNA-dependent translational repression and siRNA-dependent mRNA cleavage. It also recruits deadenylase complexes, promoting mRNA decay and gene silencing. TNRC6B has been linked to certain neurodevelopmental disorders and uterine fibroids, but it is not currently considered a direct therapeutic target, nor are there known drugs that interact with it[1][2].
- Other names
- Trinucleotide repeat containing adaptor 6BTNRC6B
02
Biological functions
RNA bindingRegulation of nuclear-transcribed mRNA catabolic processGene silencing (miRNA- and siRNA-mediated)Translational repressionmRNA endonucleolytic cleavage (by recruiting complexes with Argonaute proteins)Poly(A) tail shortening
03
Disease associations
Neurodevelopmental disorder with dysmorphic facies and distal limb anomaliesGlobal developmental delay with speech and behavioral abnormalitiesUterine fibroid, subserous uterine fibroid
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