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Target intelligence / Profile preview
Tripartite motif-containing protein 10 (TRIM10)
- Target
- TRIM10
- Molecular classification
- E3 ubiquitin ligase, Tripartite motif family protein
01
Overview
Tripartite motif-containing protein 10 (TRIM10) is a member of the TRIM family, characterized by an N-terminal RING finger, B-box zinc finger domains, and a coiled-coil region. As an E3 ubiquitin ligase, TRIM10 is implicated in protein quality control, differentiation, and survival of terminal erythroid cells. It regulates cardiac hypertrophy by promoting ubiquitination and degradation of PTEN, leading to AKT signaling activation. TRIM10 also modulates immune response by repressing STAT1/STAT2 phosphorylation in the JAK/STAT pathway. Elevated TRIM10 has been observed in pathological cardiac hypertrophy, suggesting its potential as a therapeutic target and biomarker in cardiovascular disease.
- Other names
- RFB30RNF9HERF1B30-RING finger proteinring finger protein 9Zn-finger proteinhematopoietic RING finger 1tripartite motif protein 10
02
Mechanism of action
Drugs targeting E3 ligases generally act by modulating substrate ubiquitination, but no specific mechanism for TRIM10-targeting drugs is documented
03
Biological functions
Protein ubiquitinationDiferentiation and survival of terminal erythroid cellsRegulation of immune responseRegulation of STAT1 and STAT2 phosphorylation in interferon/JAK/STAT signalingInvolvement in hypertrophic signaling via AKT pathway
04
Disease associations
Cardiovascular disease (particularly cardiac hypertrophy)Cancer (general involvement of TRIM family)Potential role in neurodegenerative disease (e.g., Parkinson’s disease, based on related studies)
05
Safety considerations
Manipulation of TRIM10 may alter cardiac hypertrophy or erythroid differentiation, posing risks such as heart failure or anemia if improperly targeted
06
Biomarkers
TRIM10 expression may serve as a biomarker for cardiac hypertrophy
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