Tripartite motif-containing protein 24 (TRIM24)

Tripartite motif-containing protein 24 (TRIM24) is a multi-domain nuclear protein belonging to the tripartite motif (TRIM) family, characterized by a RING/B-box/coiled-coil architecture, and also containing a plant homeodomain (PHD) and bromodomain that act as a combinatorial reader of specific histone modifications[1][3][4][5][6]. TRIM24 acts primarily as a chromatin-associated transcriptional coactivator, interacting with the activation function domains of several nuclear hormone receptors, including estrogen receptor (ER), androgen receptor (AR), retinoic acid, and vitamin D3 receptors[1][3][4][5]. It recruits and stabilizes transcription factors at their chromatin binding sites and modulates gene expression patterns linked to proliferation, cancer progression, and endocrine signaling[5][7]. Additionally, TRIM24 possesses E3 ubiquitin ligase activity, targeting proteins such as p53 and various innate immune pathway components for proteasomal degradation[4][6]. TRIM24 is dysregulated in multiple cancers, often acting as an oncogenic coactivator for STAT3 and nuclear receptors, and its overexpression correlates with poor prognosis, therapeutic resistance, and tumor aggressiveness[5][7]. Moreover, TRIM24 plays roles in cardiac gene expression, immune signaling, and chromatin remodeling, making it an emerging target for novel cancer therapies and a potential biomarker in oncology[2][5][7].

Other names

Transcription intermediary factor 1-alphaTIF1-alphaTIF1ARNF82E3 ubiquitin-protein ligase TRIM24RING finger protein 82RING-type E3 ubiquitin transferase TIF1-alphahTIF1PTC6TF1A

Proteasomal degradation of TRIM24 (by targeted protein degraders/PROTACs); Inhibition of TRIM24's coactivator functions (disrupting nuclear receptor or STAT3 interaction)