Tripartite motif-containing protein 49D2 (TRIM49D2)

Tripartite motif-containing protein 49D2 (TRIM49D2) is a predicted E3 ubiquitin-protein ligase implicated in protein ubiquitination, innate immune response, and regulation of gene expression; it is likely localized to the cytoplasm. There is no direct evidence supporting its role as a currently targeted therapeutic molecule, nor is it associated with specific disease or clinical biomarkers. Many of its aliases reflect status as a predicted gene or pseudogene, and its function is inferred by homology to better-studied TRIM family proteins[3]. Key clarifications: - TRIM49D2 is likely a pseudogene or predicted protein-coding gene with little published evidence of functional protein product or disease involvement; most databases classify it by homology, not experimental data[3]. - It is not considered an established therapeutic target (e.g., a receptor, enzyme targeted by drugs, transporter), nor are there drugs known to interact with TRIM49D2[3]. - Most functional annotations (ubiquitin ligase activity, immune regulation) are predictions drawn from domain structure and paralogy, not direct experimental validation for TRIM49D2 itself[3][2]. - The “incorrect” flag is true because there is no evidence this is an established drug target, and there is a high likelihood this is a non-functional or poorly characterized gene. The provided names also include multiple redundant and pseudogene-related synonyms, confirming limited functional evidence[3].

Other names

TRIM49LTRIM49L1TRIM49D2PTRIM49D1Tripartite motif-containing protein 49DTripartite motif-containing protein 49-like proteinTripartite motif-containing protein 49D1Tripartite motif-containing protein 49D2TRIM48L1TRIM49D2tripartite motif-containing protein 49Dtripartite motif-containing protein 49D2, pseudogenetripartite motif-containing protein 49-like protein 1tripartite motif-containing protein 49D1