Tripartite motif-containing protein 54 (TRIM54)

Tripartite motif-containing protein 54 (TRIM54) is a cytoplasmic E3 ubiquitin ligase belonging to the TRIM family, characterized by a RING-type domain and responsible for regulating protein degradation via the ubiquitin-proteasome pathway. Highly expressed in striated muscle, heart, and testis, TRIM54 modulates skeletal muscle development, myotube formation, and microtubule stability. In cancer cells, TRIM54 acts as an oncogene: in hepatocellular carcinoma, it promotes proliferation and metastasis by degrading Axin1 and upregulating Wnt/β-catenin signaling; in gastric cancer, TRIM54 facilitates tumor progression via K63-linked ubiquitination and degradation of filamin C. TRIM54 expression serves as a prognostic biomarker for several cancers and acute myocardial infarction. While a promising therapeutic target due to its role in multiple pathological processes (muscular, cardiovascular, oncological diseases), direct inhibitors are not currently available and its inhibition may pose risks to muscle function

Other names

TRIM54MURF3RNF30MuRF-3Muscle-specific RING finger protein 3RING finger protein 30

E3 ubiquitin ligase activity: facilitates polyubiquitination and proteasomal degradation of negative regulators such as Axin1 (leading to Wnt/β-catenin signaling activation). K63-linked ubiquitination and degradation of filamin C (FLNC), affecting cell structure and migration.