Tripartite motif-containing protein 62 (TRIM62)

Tripartite motif-containing protein 62 (TRIM62) is an E3 ubiquitin-protein ligase of the TRIM (tripartite motif) family involved in the regulation of innate immunity, antifungal responses, inflammation, and cancer. It mediates Lys-27–linked ubiquitination of CARD9, activating immune signaling pathways including NF-κB and p38 MAP kinase. Functionally, it also acts as a tumor suppressor in epithelial tissues, influences epithelial polarity, and modulates tissue morphogenesis by regulating SMAD3 and TGF-β–induced epithelial-mesenchymal transition (EMT). Loss or dysregulation of TRIM62 is associated with increased tumorigenesis, disrupted tissue homeostasis, inflammation-induced muscle wasting, and susceptibility to infection. Although not a direct target of approved drugs, TRIM62 is recognized as a key protein in innate immunity, cancer biology, and tissue remodeling.

Other names

E3 ubiquitin-protein ligase TRIM62DEAR1ductal epithelium-associated RING Chromosome 1FLJ10759RING-type E3 ubiquitin transferase TRIM62

Drugs targeting this molecule would likely act through inhibition or modulation of E3 ubiquitin ligase activity; possibly affect CARD9-mediated signaling, NF-κB activation, or TGF-β/EMT processes, but no approved mechanisms for direct pharmacological targeting of TRIM62