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Target intelligence / Profile preview
Tripartite motif-containing protein 64 (TRIM64)
- Target
- TRIM64
- Molecular classification
- Other (E3 ubiquitin ligase; Tripartite motif family/Zinc finger protein family)
01
Overview
Tripartite motif-containing protein 64 (TRIM64) is a member of the TRIM family characterized by the RBCC motif, which consists of a RING finger, one or two B-box zinc fingers, and a coiled-coil domain[1][3][5]. Most TRIM proteins act as E3 ubiquitin ligases, regulating protein stability and cellular signaling. TRIM64 is predicted to have ubiquitin-ligase activity and may play roles in the innate immune response by analogy to its family members, although its detailed function is not well-characterized. TRIM family proteins in general are important for pathogen-resistance, innate immunity, and regulation of transcriptional pathways in host defense[1][3][5]. There is currently no strong evidence for TRIM64 as a therapeutic target or a widely used disease biomarker.
- Other names
- TRIM64AC11orf28tripartite motif containing 64tripartite motif-containing protein 64
02
Biological functions
Ubiquitin-protein ligase activity (E3 ligase)Predicted role in innate immune responseRegulation of various innate immunity pathways (by analogy to TRIM family)
03
Disease associations
Other (no direct, well-characterized disease role established; some TRIM proteins are involved in cancer, immune disorders, and viral infection, but specific disease connections for TRIM64 are not well-established as of available data)
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