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tRNA (guanine(10)-N2)-methyltransferase TRMT11 (TRMT11)
- Target
- TRMT11
- Molecular classification
- Enzyme, Methyltransferase, tRNA modification enzyme
01
Overview
tRNA (guanine(10)-N2)-methyltransferase TRMT11 (abbreviated as TRMT11) is an enzyme that catalyzes the S-adenosyl-L-methionine-dependent N(2)-methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA molecules. This methylation is a post-transcriptional modification essential for proper tRNA stability and function[2][4][7]. TRMT11 functions as part of a methyltransferase complex with TRM112 and is localized predominantly in mitochondria[2][4][6]. Alteration of its activity has been associated with Combined Oxidative Phosphorylation Deficiency 7, implicating it in mitochondrial disorders[2][6]. No direct drugs, biomarkers, or major safety concerns have been reported for this target as of current sources.
- Other names
- C6orf75MDS024dJ187J11.2TRM11TRMT11-1tRNA methyltransferase 11 homolog
02
Mechanism of action
S-adenosyl-L-methionine-dependent N(2)-methylation of guanine(10) in tRNA
03
Biological functions
tRNA methylationtRNA processingRNA modificationMethylation
04
Disease associations
Combined oxidative phosphorylation deficiency 7Other (potential modifier of mitochondrial function)
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