Target intelligence / Profile preview

tRNA (guanine(37)-N(1))-methyltransferase (TRMT5)

Target: TRMT5
Molecular classification: Enzyme, tRNA methyltransferase

Overview

tRNA (guanine(37)-N(1))-methyltransferase (TRMT5) is an enzyme responsible for methylating the N1 position of guanosine-37 (G37) in various tRNAs, a critical post-transcriptional modification necessary for stable and functional tRNA structure, especially in mitochondria[3][4]. Deficiency or mutation in TRMT5 disrupts mitochondrial tRNA modification, leading to defective mitochondrial protein synthesis and is associated with multiple mitochondrial respiratory-chain deficiencies[2][3][4]. There are currently no drugs specifically known to target TRMT5 in clinical practice.

Other names: TRMT5KIAA1393TRM5COXPD26PNSEDM1G-methyltransferasetRNA [GM37] methyltransferasetRNA methyltransferase 5 homologtRNA (guanine(37)-N1)-methyltransferasetRNA-N1G37 methyltransferase

Mechanism of action

No drugs with a reported mechanism of action targeting TRMT5

Biological functions

Mitochondrial tRNA methylationPost-transcriptional modification of tRNAMaintenance of mitochondrial function

Disease associations

Mitochondrial diseases (notably multiple respiratory-chain deficiencies)[2][3]Other (diseases related to mitochondrial dysfunction)

Safety considerations

Potential role in mitochondrial disease pathology if inhibited or mutated[2][3]

Biomarkers

Mutations in TRMT5 detectable in mitochondrial disorders[2]

Beyond the preview

Go deeper on tRNA (guanine(37)-N(1))-methyltransferase (TRMT5).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on tRNA (guanine(37)-N(1))-methyltransferase (TRMT5).

Explore the full profile