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Target intelligence / Profile preview
Queuine tRNA-ribosyltransferase (TGT)
- Target
- TGT
- Molecular classification
- Enzyme, Glycosyltransferase, Pentosyltransferase
01
Overview
Queuine tRNA-ribosyltransferase (TGT) is an enzyme that catalyzes the exchange of a guanine base with queuine at position 34 (the anticodon wobble position) in specific transfer RNAs (tRNAs). This modification results in the formation of the hypermodified nucleoside queuosine within these tRNAs. It plays a role in modulating codon recognition and protein synthesis fidelity. Altered expression of TGT subunits has been linked to cancer.
- Other names
- tRNA-guanine transglycosylaseGuanine insertion enzymetRNA transglycosylaseQ-insertaseQueuine transfer ribonucleate ribosyltransferaseTransfer ribonucleate glycosyltransferaseGuanine, queuine-tRNA transglycosylase
02
Mechanism of action
Inhibition of queuine incorporation into tRNA
03
Biological functions
tRNA modificationCodon recognition modulationProtein synthesis fidelity
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to tRNA modification pathway involvement in fundamental cellular processes
06
Biomarkers
QTRT1 expression levels in cancer
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