tRNA methyltransferase 12 homolog pseudogene (TRMT12P)

The tRNA methyltransferase 12 homolog pseudogene (ENSG00000275320) is a non-functional duplicated segment of DNA derived from the protein-coding gene TRMT12, which encodes a methyltransferase involved in tRNA modification (specifically required for formation of the hypermodified nucleoside wybutosine in eukaryotic tRNA)[5][3]. As a pseudogene, ENSG00000275320 does not produce a functional protein and is not considered a direct target for drugs or as a biomarker. Pseudogenes typically arise through gene duplication or retrotransposition events and generally do not have an active biological function, though some may have regulatory roles in rare cases[6].\n\nCritical clarification: There is a functional tRNA methyltransferase 12 homolog gene (TRMT12, sometimes called TYW2)[5][3], but ENSG00000275320 is a **pseudogene** and should not be confused with the active TRMT12 gene. If you intended to request structured information for the functional TRMT12 enzyme, please clarify; the above answers pertain only to the pseudogene entry as described in your query.

Other names

TRMT12PTRMT12 pseudogenetRNA methyltransferase 12 pseudogene