tRNA methyltransferase 44 homolog (TRMT44)

tRNA methyltransferase 44 homolog (TRMT44) is a putative methyltransferase enzyme found in the cytoplasm that likely catalyzes methylation of uracil at the O(2) position in tRNA molecules, using S-adenosyl-L-methionine as the methyl donor. This protein is part of the TRM44 family and participates in tRNA modification processes important for proper RNA function. Mutations in TRMT44 have been associated in some studies with epilepsy, specifically partial epilepsy with pericentral spikes, and non-syndromic X-linked intellectual disability, though direct causality is not definitively established[2][3]. It is not generally considered a therapeutic target or receptor, and there are currently no drugs or drug mechanisms directly targeting this enzyme[1][2][3].

Other names

TRM44C4orf23METTL19methyltransferase-like protein 19probable tRNA (uracil-O(2))-methyltransferaseputative tRNA (uracil-O(2))-methyltransferaseFLJ35725