tRNA methyltransferase 6 non-catalytic subunit (TRMT6)

TRMT6 is the non-catalytic subunit of the tRNA (adenine^58^-N1)-methyltransferase complex, which forms a heterodimer with the catalytic subunit TRMT61A[3]. This complex catalyzes the methylation of adenine 58 in the T-loop of tRNA (m^1^A^58^)—a conserved modification essential for proper tRNA folding and function. TRMT6 lacks a functional methyltransferase active site but is necessary for tRNA binding and substrate specificity, facilitating the positioning of substrate tRNA for modification by TRMT61A. Disruption of TRMT6 impairs m^1^A^58^ formation and tRNA stability, impacting translation efficiency and fidelity. Deficiencies or misregulation in the complex have been linked to defects in protein biosynthesis and, in model organisms, to abnormal cellular growth and disease phenotypes[3]. Summary: - The phrase "tRNA methyltransferase 6 non-catalytic subunit" most accurately refers to TRMT6, the non-catalytic part of a methyltransferase complex (TRMT6/TRMT61A) in humans responsible for a specific tRNA adenine methylation. It is not a receptor, but a critical component required for enzymatic tRNA modification activity[3]. - The molecule is essential for cell biology but not currently targeted by drugs. - The term is somewhat imprecise—human naming conventions prefer “TRMT6” (or for the complex, “tRNA (adenine(58)-N1)-methyltransferase complex”)[3].

Other names

TRM6 (yeast homolog)TRMT6 (human gene/protein)tRNA (adenine(58)-N1)-methyltransferase non-catalytic subunit TRMT6Gcd10 in yeast

Not applicable for direct drug action, but genetic knockdown or mutation ablates tRNA m^1A^58 methylation, disrupting normal RNA processing[3].