Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
tRNA methyltransferase O (TRMO)
- Target
- TRMO
- Molecular classification
- Enzyme, RNA methyltransferase
01
Overview
tRNA methyltransferase O (TRMO) is an enzyme responsible for catalyzing the methylation of specific nucleosides within tRNA molecules, notably adding a methyl group to the C2 position of L-threonylcarbamoyladenosine(37), a highly conserved tRNA modification. This modification is important for tRNA stability and accurate decoding during protein synthesis. There are no current data supporting TRMO as a therapeutic target, nor is there evidence of it being a disease biomarker or a point of pharmacological intervention. The term "novel transcript, sense intronic to TRMO" likely describes a predicted non-coding RNA or an uncharacterized splicing product within the TRMO locus, not a validated gene with functionally characterized pharmacology or disease connection[4][2].
- Other names
- C9orf156HSPC219Q9BU70CCDS6730.1NP_057565NM_016481.4
02
Mechanism of action
None established for drugs—TRMO is not an established drug target
03
Biological functions
tRNA methylationRNA modification
04
Disease associations
No direct, well-established disease associationsnot considered an established cancer gene or hallmark gene
05
Safety considerations
None known
06
Interacting drugs
None known
07
Biomarkers
None known
Beyond the preview
Go deeper on tRNA methyltransferase O (TRMO).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on tRNA methyltransferase O (TRMO).