tRNA methyltransferase subunit 11-2 pseudogene 8 (TRMT112P8)

tRNA methyltransferase subunit 11-2 pseudogene 8 (TRMT112P8) is a processed human pseudogene, corresponding to the functional TRMT112 gene (tRNA methyltransferase activator subunit 11-2), which plays a role as an activator of several tRNA methyltransferases required for tRNA and rRNA modification[1][3][5][6]. As a pseudogene, TRMT112P8 does not encode a functional protein and lacks known biological function, disease relevance, or drug interactions[1][5][6]. Unlike some pseudogenes that may have regulatory RNA roles, there is currently no evidence in the scientific literature or major databases that TRMT112P8 exhibits any biological activity or regulatory function[1][5][6]. Therefore, it is not considered a therapeutic target, biomarker, or subject to pharmacological intervention. Pseudogenes like TRMT112P8 are usually formed by genomic duplication or retrotransposition of a functional gene, but with mutations or lack of regulatory elements that preclude protein production[6]. Some pseudogenes have regulatory properties—such as acting as competing endogenous RNAs—but TRMT112P8 has not been demonstrated to do so[4][6]. TRMT112P8 is a non-coding pseudogene, not used as a therapeutic target, and should not be confused with the functional enzyme (TRMT112) that is involved in tRNA modification. There are no known biological, clinical, or pharmacological associations with TRMT112P8.

Other names

tRNA methyltransferase 11 homolog pseudogeneTRMT112P8

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