tRNA-splicing endonuclease subunit Sen15 (TSEN15)

tRNA-splicing endonuclease subunit Sen15 (TSEN15) is a non-catalytic component of the human tRNA splicing endonuclease complex, which is responsible for the precise identification and cleavage of splice sites within intron-containing pre-tRNAs during tRNA maturation. While essential for RNA processing and normal neurodevelopment, TSEN15 itself does not possess enzymatic activity but is required for the structural integrity and function of the enzyme complex. Recessive mutations in the TSEN15 gene can cause pontocerebellar hypoplasia and progressive microcephaly, resulting in developmental delays, intellectual disability, and, less frequently, epilepsy. TSEN15 is not considered a receptor or a common therapeutic target, and no drugs are known to interact directly with this molecule.

Other names

TSEN15C1orf19SEN15sen15tRNA-splicing endonuclease subunit Sen15tRNA-splicing endonuclease subunit 15PCH2FtRNA splicing endonuclease 15 homolog