tRNA splicing endonuclease subunit Sen2 (TSEN2)

tRNA splicing endonuclease subunit Sen2 (TSEN2) is one of four subunits comprising the tRNA splicing endonuclease complex, which is essential for the removal of introns from precursor tRNAs in eukaryotic cells. TSEN2 is a catalytic subunit—responsible for the cleavage at the 5′ splice site of intron-containing pre-tRNAs, a critical step in tRNA maturation required for accurate translation and protein synthesis. Mutations in TSEN2 disrupt tRNA processing, resulting in pontocerebellar hypoplasia, a severe neurodevelopmental disorder, and may also impact other cellular RNA processing functions. The TSEN complex is ubiquitously expressed, and its enzymatic activity is tightly regulated at multiple levels; recent data suggest TSEN2 may have additional non-tRNA functions, including involvement in mRNA degradation and cellular stress response. No drugs specifically target TSEN2, and any therapeutic intervention would face substantial safety concerns due to the protein's fundamental role in cell viability.

Other names

TSEN2SEN2HsSen2SEN2LMGC2776tRNA-intron endonuclease Sen2PCH2B

Not applicable: no interacting drugs documented. If targeted, inhibition would interfere with tRNA maturation, impairing protein synthesis and cellular viability.