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Target intelligence / Profile preview
tRNA wybutosine-synthesizing protein 3 homolog (TYW3)
- Target
- TYW3
- Molecular classification
- Enzyme, Methyltransferase, tRNA modification enzyme
01
Overview
tRNA wybutosine-synthesizing protein 3 homolog (TYW3) is a protein-coding gene found across eukaryotes and archaea but not bacteria. It encodes a probable S-adenosyl-L-methionine-dependent methyltransferase that participates in the biosynthetic pathway of wybutosine (yW), a highly modified guanosine with a tricyclic base located at position 37 adjacent to the anticodon of eukaryotic phenylalanine tRNA. TYW3 catalyzes a key methylation step, using S-adenosyl-L-methionine as a methyl donor, and is essential for the maintenance of translational reading-frame fidelity on the ribosome. Mutations in TYW3 are rarely implicated in human disorders; no evidence supports its use as a therapeutic target, biomarker, or drug-binding protein.
- Other names
- tRNA-yW synthesizing protein 3 homologTYW3C1orf171tRNA wybutosine-synthesizing protein 3 homologtRNA-yW-synthesizing protein 3FLJ40918tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase
02
Biological functions
tRNA modificationTranslational fidelity
03
Disease associations
No direct, validated associations with major disease classes, but mutations in TYW3 have been linked in gene databases to rare genetic disorders such as leukodystrophy, hypomyelinating, 3; and Sjogren-Larsson syndrome—these associations are unconfirmed and rare.
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