tRNA wybutosine-synthesizing protein 5 (TYW5)

tRNA wybutosine-synthesizing protein 5 (TYW5) is an enzyme in humans that functions as a tRNA hydroxylase, specifically catalyzing the hydroxylation of a wybutosine precursor at position 37 of phenylalanine tRNA (tRNA^Phe^)[1][5][7]. It is a member of the Fe(II)/2-oxoglutarate-dependent oxygenase family, containing a Jumonji C (JmjC) domain responsible for catalytic activity[1]. TYW5 acts as part of the multistep wybutosine (yW) biosynthesis pathway, a pathway important for maintaining the proper structure and translation fidelity at the tRNA anticodon loop. The protein forms a homodimer and binds iron; its function and structure are highly conserved among eukaryotes[4][1]. The gene is located on human chromosome 2q33.1 and has several paralogs involved in related molecular modification reactions[4]. Disruptions in the TYW5 gene have been linked to rare developmental and neurodegenerative disorders, but it is not currently considered a therapeutic target or biomarker[7].

Other names

TYW5C2orf60hTYW5tRNA yW-synthesizing protein 5FLJ37953tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylasejmjC domain-containing protein C2orf60tRNA yW-synthesizing enzyme 5

no known drugs, thus no mechanisms reported