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Target intelligence / Profile preview
Trophoblast antigen 2 (TROP2)
- Target
- TROP2
- Molecular classification
- Transmembrane glycoprotein receptor
01
Overview
Trophoblast antigen 2/TROP2 is a membrane glycoprotein highly expressed across many epithelial cancers but limitedly present in normal adult tissues outside certain epithelia. It functions through multiple oncogenic pathways influencing proliferation/invasion/self-renewal. Its clinical importance lies both as a diagnostic biomarker by immunohistochemistry and as an actionable therapeutic target for antibody-drug conjugate therapies like sacituzumab govitecan.
- Other names
- Trophoblast cell surface antigen 2TACSTD2EpCAM 2
02
Mechanism of action
Antibody-drug conjugate targeting TROP2, delivering a cytotoxic payload to TROP2-expressing cells.
03
Biological functions
Cell proliferationSelf-renewalCell transformationCalcium signalingEmbryonic developmentPlacenta formationEmbryo implantationOrgan development
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to TROP2 expression in normal tissues.Toxicities associated with the cytotoxic payload of antibody-drug conjugates.
06
Interacting drugs
Sacituzumab govitecan
07
Biomarkers
TROP2 expression levels in tumor samples
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