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Target intelligence / Profile preview
Trophoblast Cell Surface Antigen 2 (Trop-2)
- Target
- Trop-2
- Molecular classification
- Transmembrane glycoprotein, Receptor
01
Overview
Trop-2 antigen is a multifunctional membrane protein central to oncogenic processes across many solid tumors due to its roles in cellular signaling related to growth/proliferation/invasion/survival. Its restricted expression pattern outside malignant contexts makes it an ideal candidate for targeted therapies currently revolutionizing outcomes for patients with advanced cancers expressing this marker.
- Other names
- TACSTD2Tumor-associated calcium signal transducer 2M1S1Membrane component chromosome 1 surface marker 1GA733-1Gastrointestinal antigen 733-1EGP-1Epithelial glycoprotein-1
02
Mechanism of action
Antibody-drug conjugate targeting Trop-2 delivers cytotoxic payload to cancer cells.
03
Biological functions
Calcium signal transductionCell proliferationSelf-renewalCell invasionCell migrationCell survivalRegulation of tight junction integrity
04
Disease associations
CancerGelatinous drop-like corneal dystrophy
05
Safety considerations
Potential for off-target effects due to Trop-2 expression in some normal tissues.
06
Interacting drugs
Sacituzumab govitecan
1 more in the full profile.
07
Biomarkers
Trop-2 expression level in tumor tissue
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