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Target intelligence / Profile preview
Trophoblast Glycoprotein (TPBG)
- Target
- TPBG
- Molecular classification
- Single-pass transmembrane glycoprotein
01
Overview
Trophoblast glycoprotein (TPBG), also known as 5T4 or WAIF1, is a single-pass transmembrane glycoprotein highly expressed in placental trophoblasts during fetal development and overexpressed in a variety of carcinomas. It plays a role in embryonic development, Wnt signaling, cell adhesion and motility, and angiogenesis. TPBG is considered an oncofetal antigen and is associated with poor prognosis in several cancers. It is a target for immunotherapy and antibody-drug conjugates.
- Other names
- 5T4Wnt-Activated Inhibitory Factor 1WAIF1M6P1Oncofetal antigen
02
Mechanism of action
Monoclonal antibodies such as mAb5T4 target TPBG for antibody-directed immunotherapy; Antibody-drug conjugates (ADCs) use TPBG as a target antigen to deliver cytotoxic drugs selectively to tumor cells; Acts as an antagonist/inhibitor within the canonical Wnt pathway; Downregulation leads to loss of E-cadherin function/cytoskeletal disruption; Orchestrates pericyte movement via modulation of chemokine axes like CXCL12/CXCR4/CXCR7/pERK.
03
Biological functions
Cell adhesionCell motilityWnt signaling regulationPericyte migrationAngiogenesisEpithelial-to-mesenchymal transition (EMT)
04
Disease associations
CancerDevelopmental Disorders
05
Safety considerations
Potential for off-target effects due to TPBG expression in normal tissues, although limited.Immunogenicity of antibody-based therapies.
06
Interacting drugs
mAb5T4
2 more in the full profile.
07
Biomarkers
TPBG expression level in tumor tissue
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