Tropomodulin 1 (TMOD1)

Tropomodulin 1 (TMOD1) is a pivotal actin filament pointed-end capping protein that binds to and caps the slow-growing (minus or pointed) ends of actin filaments, thereby regulating their length and stability[1][2][3][4][5]. TMOD1 exerts its function in coordination with tropomyosin by preventing both the addition and loss of actin subunits at the pointed end, a mechanism critical for maintaining the structure and function of the erythrocyte membrane skeleton, striated muscle sarcomeres, and various non-muscle contractile and structural cytoskeletal architectures[1][3][4][5]. TMOD1 is particularly important in erythrocytes, heart, slow skeletal muscle, neurons (where it supports spine morphogenesis and synapse formation), and specialized epithelial cells[1][3][4]. Disruptions or mutations in TMOD1 are implicated in hereditary anemias, cardiac diseases, neurodevelopmental disorders, and certain cancers, reflecting its central role in cellular structure and stability[1][4]. No drugs or small molecules are currently known to specifically target TMOD1 in clinical use, and it is not a classical therapeutic target such as a receptor, enzyme, transporter, or ion channel[4].

Other names

Tropomodulin-1D9S57ETMODE-TmodETMODErythrocyte tropomoduline-tropomodulin