Tropomodulin-2 (TMOD2)

Tropomodulin-2 (TMOD2) is a brain-specific isoform of the tropomodulin family of actin-regulatory proteins, encoded by the *TMOD2* gene in humans[1][2][3]. TMOD2 functions by capping the pointed (minus) end of actin filaments in the neuronal cytoskeleton, thereby inhibiting both filament elongation and depolymerization—a process that is critically dependent on interaction with tropomyosin[1][2][3][4]. This pointed-end capping activity is essential for the regulation of actin filament architecture, especially in neurons, where TMOD2 is a main controller of dendritic spine formation, maturation, and synaptic plasticity[1]. Alterations in TMOD2 expression modulate spine number and shape and can impact higher-order neuronal functions, as shown by learning and memory deficits when TMOD2 is deleted in animal models[1]. TMOD2 is not known to be directly targeted by drugs, and its current biomedical relevance is limited to fundamental cell biology and select inherited neurological disorders rather than as a therapeutic target[3].

Other names

Tropomodulin-2TMOD2Neuronal tropomodulinNTMODN-TmodN-TMOD