Tropomodulin-4 (TMOD4)

Tropomodulin-4 (TMOD4) is a member of the tropomodulin protein family and the predominant isoform in mammalian skeletal muscle. It acts as an actin-capping protein, binding to the pointed (minus) end of actin filaments, where it blocks both elongation and depolymerization. This function is essential for regulating thin filament length, maintaining sarcomere structure, and enabling effective muscle contraction. TMOD4’s activity is tropomyosin-dependent; it helps ensure the integrity of myofibrils during muscle development. Disruption of TMOD4 impairs sarcomere assembly and muscle organization, and it may be genetically associated with certain myopathies and forms of amyotrophic lateral sclerosis. TMOD4 is not known to be a direct target of any current drugs, nor is it used as a clinical biomarker or therapeutic agent.

Other names

Skeletal muscle tropomodulinactin-capping proteinskeletal tropomodulinSK-TMODSk-Tmodtropomodulin 4 (muscle)

no drugs known to act via TMOD4, so no therapeutic mechanism; its biological role is actin filament capping and stabilization