Tropomyosin 3 pseudogene

Tropomyosin 3 pseudogene, referred to by Ensembl as ENSG00000253362, is a nonfunctional DNA segment that closely resembles the functional gene *tropomyosin 3* (TPM3) but has lost its protein-coding potential[1][4][5]. Pseudogenes like this often arise due to mutations, frameshifts, or premature stop codons that disrupt the encoding sequence[2][5]. As a result, tropomyosin 3 pseudogene does not encode for a functional protein and is not considered a therapeutic target or biologically active receptor, enzyme, or transporter[1][2][4][5]. Most pseudogenes—including this one—may be transcribed at low levels into RNA but typically lack functional protein products and recognized disease involvement, though recent research has suggested that some pseudogene transcripts may play a regulatory role in gene expression or interact with other RNAs[8]. There is no evidence that the tropomyosin 3 pseudogene itself has therapeutic relevance, interacts with drugs, serves as a biomarker, or presents safety concerns as a drug target. Note: This entry is a *pseudogene*, meaning it is not a biologically active target, and should be distinguished from the functional gene *tropomyosin 3* (TPM3)[1][5]. Only the protein-coding TPM3 gene, not its pseudogenes, has recognized roles in muscle contraction, cancer, and therapeutic contexts[3][6]. The presence of a pseudogene in a target list for therapeutic interest likely indicates a data or annotation error.

Other names

Tropomyosin 3 (TPM3) pseudogene