Tropomyosin 3 pseudogene 3 (TPM3P3)

Tropomyosin 3 pseudogene 3 (TPM3P3) is a transcribed pseudogene related to the functional TPM3 gene, which encodes for a tropomyosin involved in the regulation of actin filaments and muscle contraction. Pseudogenes like TPM3P3 generally do not encode functional proteins due to mutations or truncations, but may have regulatory roles at the RNA level, including acting as decoys for microRNAs or modulating the expression of their parental gene. No evidence currently supports a defined biological function, disease association, or clinical relevance for TPM3P3 as an individual entity. Pseudogenes are genomic DNA sequences similar to normal genes but typically nonfunctional due to disabling mutations or lack of regulatory elements. While a growing number of pseudogenes demonstrate RNA-level regulatory roles and may influence disease states, most remain poorly characterized, and their clinical relevance is limited compared to protein-coding genes. Canonical therapeutic targets are generally protein-coding genes; pseudogenes like TPM3P3 are not considered classical drug targets.