Tropomyosin 3 pseudogene 5 (TPM3P5)

Tropomyosin 3 pseudogene 5 (TPM3P5) is a processed pseudogene found in the human genome. Pseudogenes are nonfunctional DNA segments that resemble their parent genes but typically contain mutations (such as truncations or frame shifts) preventing protein production. While some pseudogenes act as regulatory noncoding RNAs, there is no specific evidence TPM3P5 has such a function. It does not code for any protein, is not a therapeutic target, is not involved in any known signaling or disease process, and is not used as a biomarker. Its nomenclature is standardized according to human gene naming conventions for pseudogenes: "Tropomyosin 3 pseudogene 5" (TPM3P5). The functional parent gene, TPM3 (tropomyosin 3), is an actin-binding protein involved in muscle contraction and is relevant in certain diseases like cancer or myopathies, but TPM3P5 does not code for any protein and is not part of those pathways. Pseudogenes like TPM3P5 are "dead on arrival" due to mutations or lack of promoters, and do not serve in the canonical roles of receptors, enzymes, or proteins. Pseudogenes can sometimes regulate gene expression via noncoding RNA mechanisms, but such a role is unconfirmed for TPM3P5.

Other names

NCBI Gene 644330

None relevant (no therapies or drugs known to act by targeting TPM3P5)