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Target intelligence / Profile preview
Tropomyosin Receptor Kinase C (TrkC)
- Target
- TrkC
- Molecular classification
- Receptor Tyrosine Kinase, Receptor
01
Overview
Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase, is a transmembrane protein encoded by the *NTRK3* gene in humans. It belongs to the family of tropomyosin receptor kinases (TrkA, TrkB, and TrkC), which are part of the larger group of receptor tyrosine kinases. TrkC is the high-affinity catalytic receptor for neurotrophin-3 (NT-3) and plays an essential role in nervous system development and function. Alterations in TrkC expression or function have been linked to several diseases, including neurodegenerative diseases and cancer.
- Other names
- NT‑3 growth factor receptorNeurotrophic tyrosine kinase receptor type 3TrKC tyrosine kinase
02
Mechanism of action
TRK inhibitor therapies targeting NTRK gene fusions
03
Biological functions
Neuronal differentiationNeuronal survivalSynaptic plasticityCell proliferationCell survivalSignal transduction
04
Disease associations
Neurodegenerative diseaseCancer
05
Interacting drugs
Entrectinib
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