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Target intelligence / Profile preview
Tropomyosin-related Kinase Family (Trk)
- Target
- Trk
- Molecular classification
- Receptor, Tyrosine Kinase Receptor, Enzyme, Receptor Tyrosine Kinase
01
Overview
The tropomyosin-related kinase (Trk) family is a group of receptor tyrosine kinases that play essential roles in the development and function of the nervous system. The family consists of three members: TrkA, TrkB, and TrkC. Each receptor binds to different neurotrophins and activates intracellular signaling cascades that regulate neuronal survival, differentiation, and synaptic plasticity. Aberrant activation of Trk receptors, often through gene fusions, can contribute to oncogenesis, making them therapeutic targets for cancer therapy.
- Other names
- Neurotrophic tyrosine kinase receptor familyTRKATRKBTRKCNeurotrophin Receptor FamilyTropomyosin Receptor Kinase Family
02
Mechanism of action
Small-molecule inhibitors targeting TRKs inhibit the kinase activity of the receptors, preventing autophosphorylation and downstream signaling.
03
Biological functions
Signal transductionNeuronal survivalNeural differentiationAxon/dendrite growthSynaptic plasticityCell growthCell maturationCell proliferationCell migration
04
Disease associations
Neurological disordersCongenital insensitivity to pain with anhidrosisIntellectual disabilityCognitive impairmentCancer
05
Safety considerations
On-target toxicitiesOff-target effectsResistance to TRK inhibitorsDevelopment of secondary mutationsNeurotoxicity
06
Interacting drugs
TRK inhibitors (small-molecule inhibitors)
3 more in the full profile.
07
Biomarkers
NTRK gene fusionsTRK protein overexpressionNTRK1 gene mutationsNTRK2 gene mutationsNTRK3 gene mutations
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