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Target intelligence / Profile preview
Tropomyosin-related kinase B (TRKB)
- Target
- TRKB
- Molecular classification
- Receptor Tyrosine Kinase
01
Overview
Tropomyosin-related kinase B (TRKB) is a receptor tyrosine kinase that plays a crucial role in neuronal survival, differentiation, and synaptic plasticity. It is a high-affinity receptor for BDNF, NT4/5, and NT3. Activation of TRKB initiates multiple downstream signaling cascades including Ras-MAPK/ERK, PI3K-Akt, and PLCγ. Aberrant activation or overexpression of TRKB/NTRK2 has been implicated in various diseases, including cancer and psychiatric conditions.
- Other names
- TrkBNTRK2
02
Mechanism of action
Selective TRKB inhibitors and Pan-Trk inhibitors block the kinase activity of TRKB, inhibiting downstream signaling pathways such as Ras-MAPK/ERK, PI3K-Akt, and PLCγ.
03
Biological functions
Neuronal survivalNeuronal differentiationSynaptic plasticityAstrocyte maturationGrowthMaintenance
04
Disease associations
CancerNeurogenic tumorsPsychiatric disordersNeurodevelopmental disordersDepressionAnxietyLearning/memory disorders
05
Interacting drugs
Selective TRKB inhibitors
1 more in the full profile.
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