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Target intelligence / Profile preview
Tropomyosin-related kinase receptor type B (TrkB)
- Target
- TrkB
- Molecular classification
- Receptor tyrosine kinase, Transmembrane receptor
01
Overview
Tropomyosin-related kinase receptor type B (TrkB) is a receptor tyrosine kinase encoded by the NTRK2 gene. It is a high-affinity receptor for neurotrophins, particularly brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5), and plays a critical role in neuronal survival, differentiation, development, and synaptic plasticity. Abnormal TrkB activation is implicated in tumorigenesis and may confer resistance to therapies, making it a target for anti-cancer therapy.
- Other names
- NTRK2neurotrophic receptor tyrosine kinase 2
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Neuronal survivalNeuronal differentiationSynaptic plasticityAxonal growthDendritic growthAstrocyte maturationSignal transduction
04
Disease associations
CancerNeurogenic tumors
05
Safety considerations
Tumorigenesis via overexpression/fusionResistance to therapies
06
Interacting drugs
Selective TrkB inhibitors
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