Target intelligence / Profile preview

Troponin C, slow skeletal and cardiac muscles (cTnC)

Target: cTnC
Molecular classification: Calcium-binding protein, Troponin subunit, EF-hand protein

Overview

Troponin C (cTnC), encoded by the TNNC1 gene, is a calcium-binding protein expressed in cardiac and slow skeletal muscle. It is a crucial component of the troponin complex, regulating muscle contraction by binding calcium ions and initiating the actin-myosin interaction. Mutations in TNNC1 are associated with cardiomyopathies.

Other names: TNNC1Troponin C type 1Cardiac troponin CSlow skeletal troponin C

Mechanism of action

Calcium binding leading to conformational change and activation of actomyosin ATPase.

Biological functions

Calcium bindingMuscle contraction regulationSarcomere function

Disease associations

Hypertrophic cardiomyopathyRestrictive cardiomyopathyDilated cardiomyopathy

Safety considerations

Modulation of cTnC can have significant effects on cardiac contractility, requiring careful consideration of potential adverse effects.

Biomarkers

Elevated cTnC levels can indicate cardiac damage (though other troponins are more specific markers)

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