TRPC5 opposite strand protein (TRPC5OS)

TRPC5 opposite strand protein (TRPC5OS) is the antisense transcript of the TRPC5 gene, referred to as TRPC5 antisense RNA 1 (TRPC5-AS1). This gene encodes a small microprotein (111 amino acids) found primarily in testis and abnormally upregulated in breast and other cancers. Functional studies in breast cancer cells show that TRPC5OS overexpression promotes cell division and proliferation, with gene ontology linking its activity to regulation of these processes and signaling pathways such as homologous recombination and TNF. Seventeen proteins have been identified as potential interaction partners, including ENO1 (enolase 1), which is involved in glycolysis and may contribute to the cancer-promoting activity of TRPC5OS. Current research makes TRPC5OS a promising candidate as a therapeutic target and molecular marker in oncology, especially for triple-negative breast cancer. If further specificity or references to interacting drugs, clinical biomarkers, or detailed safety considerations become available, this should be updated.

Other names

TRPC5OSTRPC5-AS1TRPC5 opposite strand proteinTRPC5 antisense RNA 1Putative uncharacterized protein TRPC5OS

Not established for drugs; for biological effect, overexpression increases cancer cell proliferation and affects gene expression involving cell cycle and metabolic regulation